UNIVERSITÉ PARIS-SUD 11;DA VOLTERRA;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;UNIVERSITÉ PARIS DIDEROT - PARIS 7;ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
发明人:
HUGUET, HÉLÈNE,ANDREMONT, ANTOINE
申请号：
ES07765272
公开号：
ES2472703T3
申请日:
2007.05.18
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
Use of an orally administrable pharmaceutical composition for intestinal release of specific site of adsorbents, comprising an adsorbent selected from the group consisting of activated carbon, clays, talc, silica and resins； and a specific site delivery system for releasing the adsorbent in the ileum or colon, wherein the delivery system is coated with a coating material or a combination of coating materials selected from: cellulosic polymers such as hydroxypropylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose acetate succinate, hydroxypropylmethylcellulose phthalate, methylcellulose, ethylcellulose, cellulose acetate, cellulose acetate phthalate, cellulose acetate trimellitate and sodium carboxymethylcellulose； polymers and copolymers of acrylic acid formed from acrylic acid, methyl acrylate, ethyl acrylate, methyl methacrylate and / or ethyl methacrylate, or which are a tercopolymer of methacrylic acid, methyl acrylate and methyl methacrylate； vinyl polymers and copolymers such as polyvinylpyrrolidone, vinyl acetate, vinyl acetate phthalate, vinyl acetate and crotonic acid copolymer, and ethylene-vinyl acetate copolymer； Enzymatically degradable polymers such as azo and amylose polymers； zein； and lacquer, to prepare a medicament to treat or prevent the adverse effects of an antibiotic on the intestinal flora, or to treat or prevent the adverse effects of a pharmaceutically active agent that has beneficial effects when it binds or interacts with targets outside the colon, but it has adverse side effects when it joins or interacts with targets within the colon.Uso de una composición farmacéutica administrable por vía oral para la liberación intestinal de sitio específico de adsorbentes, que comprende un adsorbente seleccionado del grupo que consiste en carbón activado, arcillas, talco, sílice y resinas； y un sistema de suministro de sitio específico para liberar el adsorbente en el íleon o el colo
