PROBLEM TO BE SOLVED: To provide means for lowering blood glucose levels in an animal.SOLUTION: A pancreatic endocrine precursor cell population to be transplanted into an animal is obtained by (a) differentiating an embryonic endoderm cell population into a pancreatic endoderm cell population and (b) differentiating the pancreatic endoderm cell population into the pancreatic endocrine precursor cell population in a DMEM-high glucose medium.SELECTED DRAWING: None【課題】 動物の血糖値を低下させるための手段の提供。【解決手段】（ａ）胚体内胚葉細胞集団の膵臓内胚葉細胞集団への分化工程、及び（ｂ）ＤＭＥＭ－高グルコース培地中での膵臓内胚葉細胞集団の膵内分泌前駆細胞集団への分化工程により得られ、かつ、動物に移植されるべきものである膵内分泌前駆細胞集団。【選択図】なし
