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Condensed Heterocyclic substituted as GPR119 modulators for the treatment of diabetes, obesity, dyslipidemia and Related Disorders
专利权人:
SANOFI
发明人:
申请号:
ARP150100989
公开号:
AR099936A1
申请日:
2015.04.01
申请国别(地区):
AR
年份:
2016
代理人:
摘要:
Condensed Heterocyclic substituted compounds. Condensed Heterocyclic compounds modulating GPR119 are replaced and are useful for the Prevention and / or treatment of diabetes, obesity, dyslipidemia and Related Disorders.In addition, the use of substituted Condensed Heterocyclic compounds as active ingredients in Pharmaceuticals, and the pharmaceutical compositions containing them.Claim 1: a compound of the formula (1) in which a is n or C, B is n or CH, and Co, is n or C; g is n or cr u00b3 u2070; where at least one of the groups a, B, e or g is n; r u00b3 u2070 is H OR (cr u00b9 u00b9r u00b9 u00b2 u2099 - r u00b3 u00b2); r u00b9 u00b9 r u00b9 u00b2 are, independently of one another c u2081 u208b u2086 H or alkyl; n is 0, 1, 2, or 3; r u00b3 u00b2 is c u2081 u208b u2086 c u2083 u208b u2088 alkyl, cycloalkyl, coor u00b9 u00b3, conr u00b9 u2074r u00b9 u2075, so u2082r u00b9 u2076 or Oh; r u00b9 u00b3 is H or alkyl r u00b9 u2074, c u2081 u208b u2086;R u00b9 u2075 are independently of each other c u2081 u208b u2086 c u2081 u208b u2086 h, alkyl, alkyl or cycloalkyl substituted with or u00b9 u2077, c u2083 u208b u2086; or r u00b9 u2074 and r u00b9 u2075 form together with the atom of the heterocycle that are United, one of 4, 5 or 6 members, which optionally contains an additional Atom s The list of eleccionado o, s and nr u00b9 u2078 where heterocycle; 4.5 or 6 members can be optionally replaced with 1 to 3 groups selected from the list of c u2081 u208b u2084 alkyl and alkyl or u00b9 u2077; r u00b9 u2076 is c u2081 u208b u2086; r u00b9 u2077 is H or alkyl c u2081 u208b u2086; r u00b9 u2078 is H or alkyl c u2081 u208b u2086; r u00b9 u1d43, r u00b9 u1d47 are independently of each other, r u00b9 u1d9c h, F, CL, BR, Rent c u2081 u208b u2086 or CN; r u00b2 u1d43, r u00b2 u1d47 are independently of each other, r u00b2 u1d9c h, F, CL, BR, or rent c u2081 u208b u2086 CN; and Z is n or CH, is a Link, or cr u2075r u2075 nr u2076,,,C = o, S, so, or SO u2082; r u2075, r u2075 are
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