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ПРИМЕНЕНИЕ АНАЛОГОВ 4-ДЕСФЕРРИТИОЦИНА
专利权人:
ЮНИВЕРСТИТИ ОФ ФЛОРИДА РИСЕЧ ФАУНДЭЙШН; ИНК. (US)
发明人:
БЕРГЕРОН Реймонд Дж. (US)
申请号:
RU2014128756
公开号:
RU2014128756A
申请日:
2012.12.14
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A method of treating macular degeneration in a subject comprising administering to the subject a therapeutically effective amount of a compound of Formula (I): wherein: R1 represents hydrogen, alkyl or acyl R2 represents hydrogen, alkyl or - [(CH2) nO] x- [ (CH2) nO] yR R3, R4 and R5 each independently represents hydrogen, alkyl, arylalkyl, or -OR10 R6, R7 and R8 each independently represents hydrogen, halogen, alkyl or -OR12 R9 is -OR11 or -SR11 R10 represents hydrogen, alkyl or acyl R11 is hydrogen or alkyl R12 represents in portly or alkyl R represents alkyl, in each case, n independently represents an integer from 1 to 8 inclusive x is an integer from 1 to 8 inclusive and Y is an integer from 0 to 8 inclusive or a pharmaceutically acceptable salt, tautomer, solvate, hydrate or polimorfaR1 represents hydrogen, alkyl or acyl R2 represents - [(CH2) nO] x - [(CH2) nO] yR or alkyl R3, R4 and R5 each independently represents hydrogen, alkyl or -OR10 R6, R7 and R8 each independently represents hydrogen or alkyl R9 is -OR11 R10 represents hydrogen, alkyl or acyl R11 It represents hydrogen or alkyl R represents alkyl, in each case, n independently represents an integer from 1 to 8 inclusive x is an integer from 1 to 8 inclusive and Y is an integer from 0 to 8 inclusive or a pharmaceutically acceptable salt, tautomer, solvate or gidrata.2. A method of treating a closed head injury in a subject comprising administering to the subject a therapeutically effective amount of a compound of formula (I): wherein: R1 represents hydrogen, alkyl or acyl R2 represents hydrogen, alkyl or - [(CH2) nO] x - [(CH2 ) nO] yR R3, R4 and R5 each call
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