COMPOSITIONS ET PROCÉDÉS D'ACTIVATION DE LA SIGNALISATION DÉPENDANTE DE « STIMULATEUR DE GÈNES D'INTERFÉRON »

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专利权人:

Aduro BioTech, Inc.;Novartis AG

发明人:

KATIBAH, George, Edwin,KANNE, David,SUNG, Leonard,GAUTHIER, Kelsey,GLICKMAN, Laura, Hix,LEONG, Justin,McWHIRTER, Sarah, M.,DUBENSKY, Thomas, W., Jr.,McKENNA, Jeffrey,CANHAM, Stephen, M.,NDUBAKU, Chudi

申请号：

EP16860959

公开号：

EP3368072A4

申请日:

2016.10.28

申请国别(地区):

EP

年份:

2019

代理人:

摘要：

The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce human STING-dependent type I interferon production, wherein the cyclic purine dinucleotides present in the composition are 2′- or 3′-mono-fluoro substituted, or 2′3′-di-fluoro substituted mixed linkage 2′,5′-3′,5′ CDNs.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/