EUI HWAN CHO,HEE JONG SHIN,HO JOON PARK,HO SEOK KWON,HO TAE NAM,HYUN TAE KIM,JAE WOONG LEE,JEONG HO JOO,JONG BAE YOON,KI SEOK PARK,SUNG JU CHOI,SUNG WOO LEE,WOO HEON SONG
申请号：
BR112014032627
公开号：
BR112014032627A2
申请日:
2013.06.26
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
abstract disclosed are a novel rebamipide prodrug, a method for preparing the same, and using it. Also, a pharmaceutical composition comprising the novel rebamipide prodrug as an active ingredient is provided. the rebamipide prodrug is increased 25-fold in absorption rate compared to rebamipide itself, and can be applied to the prophylaxis or therapy of gastric ulcer, acute gastritis, chronic gastritis, xerophthalmia, cancer, osteoarthritis, rheumatoid arthritis, or obesity. Patent Summary: "Rebamipide prodrugs, method for producing the same, and use thereof". The present invention relates to a novel rebamipide prodrug, a method for producing the same, and use thereof, and more specifically to a novel rebamipide prodrug, a method for producing the same and a pharmaceutical composition containing The same as an active ingredient. The novel rebamipide prodrug according to the present invention has a body absorption rate of approximately 25 times the absorption rate of rebamipide, and thus can be effectively used in place of rebamipide in the prevention or treatment of gastric ulcer, acute and chronic gastric, dry eye syndrome, cancer, degenerative joint disease, rheumatoid arthritis, or obesity. fig. 1 figure caption: - prodrug - rebamipideabstract disclosed are a novel rebamipide prodrug, a method for preparing the same, and use thereof. also, a pharmaceutical composition comprising the novel rebamipide prodrug as an active ingredient is provided. the rebamipide prodrug is increased 25-fold in absorption rate compared to rebamipide itself, and can be applied to the prophylaxis or therapy of gastric ulcer, acute gastritis, chronic gastritis, xerophthalmia, cancer, osteoarthritis, rheumatoid arthritis, or obesity. tradução do resumo resumo patente de invenção: "pró-fármacos de rebamipida, método para produzir o mesmo, e uso do mesmo". a presente invenção refere-se a um novo pró-fármaco de rebamipida, um método para produzir o mesmo, e uso do mesmo, e mais especificamen
