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Protective vaccine based on Staphylococcus aureus SA2451 protein
专利权人:
Merck Sharp & Dohme Corp.
发明人:
Tessie McNeely,Donna Lorraine Montgomery,Leslie Cope,Amita Joshi,Gregory P. Pancari,Hongxia Fan
申请号:
US14354948
公开号:
US09527892B2
申请日:
2012.10.26
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The present invention relates to methods of inducing an immune response to Staphylococcus comprising administering a composition comprising an SA2451-related polypeptide from Staphylococcus aureus as well as derivatives or fragments thereof. The present invention also encompasses methods of treating and/or reducing the likelihood of a Staphylococcus infection by administering a composition comprising an SA2451-related polypeptide or an antibody that specifically binds to an SA2451 polypeptide, derivative or fragments thereof. Compositions administered in the methods of the invention can include one or more additional antigens. Compositions used to practice the methods of the invention are also encompassed.
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