Provided are anti-epidermal growth factor receptor (EGFR) antibodies, aglycosylated CDR-H2 anti-EGFR antibodies, and antigen binding fragments thereof. Also provided are isolated nucleic acid molecules that encode the anti-EGFR antibodies or antigen binding fragments thereof, related expression vectors, and host cells. Provided are methods of making anti-epidermal growth factor receptor (EGFR) antibodies, aglycosylated CDR-H2 anti-EGFR antibodies, and antigen binding fragments thereof. Also provided are related pharmaceutical compositions and methods of their use to treat subjects.本發明提供抗表皮生長因子受體(EGFR)抗體、CDR-H2去糖基化之抗EGFR抗體及其抗原結合片段。亦提供編碼抗EGFR抗體或其抗原結合片段之經分離核酸分子、相關表現載體及宿主細胞。提供製備抗表皮生長因子受體(EGFR)抗體、CDR-H2去糖基化之抗EGFR抗體及其抗原結合片段之方法。亦提供相關醫藥組合物及其用於治療個體之方法。
