Disclosed are an exenatide modifier for connecting the exenatide to a fatty chain with a carboxy in the terminus thereof by means of a hydrophilic connecting arm, and a use thereof in preparing drugs serving as a GLP-1 receptor agonist； a use in preparing drugs for preventing and/or treating diseases and/or symptoms associated with a low GLP-1 receptor activity； a use in preparing drugs for diseases and/or symptoms associated with glycometabolism； a use in preparing drugs for diabetes； a use in preparing drugs for fatty liver disease； and a use in preparing drugs for losing weight.
