In a first aspect, the invention provides a polymeric nanoparticle comprising at least one polycationic polymer at least one polyanionic polymer and a therapeutically effective amount of at least one therapeutic agent. In a second aspect, the invention provides a method for the preparation of a polymeric nanoparticle according to the first aspect the method comprising the steps of: (i) admixing the at least one polyanionic polymer with the at least one therapeutic agent and (ii) introducing to the mixture of (i), to the at least one polycationic polymer. In a third aspect, the invention provides a polymeric nanoparticle according to the first aspect of the present invention, or a polymeric nanoparticle prepared according to the second aspect of the present invention for use in the treatment of an inflammatory and/or arthritic disorder caused by or associated with dysfunctional nuclear receptor signalling.
