The Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth;University College Dublin, National University of Ireland, Dublin
In a first aspect, the invention provides a polymeric nanoparticle comprising at least one polycationic polymer； at least one polyanionic polymer； and a therapeutically effective amount of at least one therapeutic agent.In a second aspect, the invention provides a method for the preparation of a polymeric nanoparticle according to the first aspect； the method comprising the steps of: (i)admixing the at least one polyanionic polymer with the at least one therapeutic agent； and (ii) introducing to the mixture of (i), to the at least one polycationic polymer.In a third aspect, the invention provides a polymeric nanoparticle according to the first aspect of the present invention, or a polymeric nanoparticle prepared according to the second aspect of the present invention； for use in the treatment of an inflammatory and/or arthritic disorder caused by or associated with dysfunctional nuclear receptor signalling.
