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Substituted (E)-N'-(1-phenylethylidene) benzohydrazide analogs as histone demethylase inhibitors
专利权人:
University of Utah Research Foundation
发明人:
Vankayalapati, Hariprasad,Sorna, Venkataswamy,Warner, Steve L.,Bearss, David J.,Sharma, Sunil,Stephens, Bret
申请号:
AU2012296639
公开号:
AU2012296639B2
申请日:
2012.08.15
申请国别(地区):
AU
年份:
2016
代理人:
摘要:
In one aspect, the invention relates to substituted (E)-N'-(1- phenylethylidene)benzohydrazide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of lysine-specific histone demethylase, including LSD1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the LSD1. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
来源网站:
中国工程科技知识中心
来源网址:
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