Martin Fussenegger,Wilfried Weber,Ronald Schoenmakers
申请号：
US12808801
公开号：
US09050295B2
申请日:
2008.11.25
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention relates to a pharmaceutical composition comprising a compound preventing EthR from binding to the ethA promoter, for example a compound of formula 1 wherein R1 is optionally substituted phenyl or optionally substituted pyridyl R2 (CH2)n wherein n is 1, 2, 3 or 4 R3 is CH3(CH2)m wherein m is 0, 1, 2 or 3 X1 is O, S, NH, N(CH3) or CH2 and X2 is O, S or NH in particular 2-phenylethyl butyrate, and a thioamide or thiourea of formula 2 wherein R4 is optionally substituted phenyl, optionally substituted pyridyl, optionally substituted indolyl, —NR7R8 or —NH—N═CH—R9 and substituents R5 to R9 have the meanings indicated in the description, in particular ethionamide. The pharmaceutical composition is useful, e.g., in the treatment of multidrug-resistant tuberculosis.
