<;P>;PROBLEM TO BE SOLVED: To provide a control factor of Rab27A which engages in the transport of a melanosome. <;P>;SOLUTION: This Rab27A deactivator contains either one of the following (a)-(d): (a) a protein consisting of an amino acid sequence expressed with sequence number 2, or a protein consisting of an amino acid sequence deleted, permuted, or added with one or a few amino acids in a protein consisting of an amino acid sequence expressed with sequence number 2, and having Rab27A GTP-ase activity promoting action; (b) a protein consisting of an amino acid sequence expressed with sequence number 4, or a protein consisting of an amino acid sequence deleted, permuted, or added with one or a few amino acids in a protein consisting of an amino acid sequence expressed with sequence number 4, and having Rab27A GTP-ase activity promoting action; (c) a gene coding the (a) or (b) protein; and (d) a recombinant vector containing the gene coding the above (a) or (b) protein. <;P>;COPYRIGHT: (C)2007,JPO&INPIT