The present invention is an ophthalmic composition, which contains Diquafosol or a salt thereof, and a cationic polymer, and the cationic polymer is selected from the group consisting of polyglucosamine and polyglucosamine derivatives , Cationic (meth) acrylate copolymer, cationic silicone polymer, diallyl quaternary ammonium salt, acrylamide copolymer, cationic hydrolyzed keratin, cationic hydrolyzed silk, cationic hydrolyzed collagen , Cationic hydrolyzed casein, cationic hydrolyzed soy protein, cationic vinyl pyrrolidone copolymer, polyvinyl pyrrolidone, homopolymer of dimethyldipropenyl ammonium chloride, adipic acid, dimethyl Aminoaminohydroxypropyldiethylene triamine copolymer, adipic acid · epoxypropyldiethylene triamine copolymer, and acrylamide · β-methacryloxyethyltrimethyl At least one of the group consisting of an ammonium methyl sulfate copolymer.本發明係一種眼科用組合物，其係含有迪夸弗索(Diquafosol)或其鹽、及陽離子性聚合物者，且該陽離子性聚合物係選自由聚葡萄胺糖、聚葡萄胺糖衍生物、陽離子性(甲基)丙烯酸酯共聚物、陽離子性矽酮聚合物、二烯丙基四級銨鹽·丙烯醯胺共聚物、陽離子性水解角蛋白、陽離子性水解蠶絲、陽離子性水解膠原蛋白、陽離子性水解酪蛋白、陽離子性水解大豆蛋白、陽離子性乙烯基吡咯啶酮共聚物、聚乙烯基吡咯啶酮、氯化二甲基二丙烯基銨之均聚物、己二酸·二甲基胺基羥基丙基二伸乙基三胺共聚物、己二酸·環氧丙基二伸乙基三胺共聚物、及丙烯醯胺·β-甲基丙烯醯氧基乙基三甲基銨甲基硫酸鹽共聚物所組成之群中之至少1種。
