An contact lens or intraocular lens (IOL) with very high water content polymers that have increased hydrolytic stability to withstand high temperatures such as autoclave temperatures, l23℃ or even higher temperatures while in an aqueous environment comprising at least one polymer comprising one or more monomeric subunits comprising a polymerized acrylamide or methacrylamide group, at least one side group comprising an aliphatic carbon moiety substituted by at least one hydroxyl moiety, wherein the one or more monomeric subunits comprising a polymerized acrylamide or methacrylamide group, at least one side group comprising an aliphatic carbon moiety substituted by at least one hydroxyl moiety, comprise at least 50 wt.% of the polymer.本發明係關於一種具有非常高水含量聚合物之隱形眼鏡或眼內透鏡(IOL)，該等聚合物當處於含水環境中時具有提升之水解穩定性以耐受高溫諸如高壓釜溫度(123℃)或甚至更高溫度，其包括至少一種包括一或多個單體子單元之聚合物，該等單體子單元包括聚合之丙烯醯胺或甲基丙烯醯胺基團、至少一個包括經至少一羥基部分取代之脂肪族碳部分之側基，其中該等一或多個包括聚合之丙烯醯胺或甲基丙烯醯胺基團、至少一個包括經至少一羥基部分取代之脂肪族碳部分之側基的單體子單元佔該聚合物之至少50重量%。
