ABRAHMSEN, LARS,HERNE, NINA,FELDWISCH, JOACHIM,LENDEL, CHRISTOFER,TOLMACHEV, VLADIMIR
申请号：
CA2709915
公开号：
CA2709915C
申请日:
2008.12.22
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
HER2 binding polypeptides comprising the amino acid sequence EX, RNAYWEIALLPNLTNQQK RAFIRKLYDDPSQSSELLX2E AKKLNDSQ wherein X1 in position 2 is M, I or L, and X2 in position39 is S or C (SEQ ID NO:1 ) aredisclosed. Moreover, such peptides comprising a chelating environment aredisclosed. Also radiolabeled polypeptides formed by thepeptides comprising a chelating environment and radionuclides are disclosed.Furthermore, methods of in vivo imaging of the bodyof a mammalian subject having or suspected of having a cancer characterized byoverexpression of HER2 comprising administrationof such a radiolabeled polypeptide followed by obtainment of an image of thebody using a medical imaging instrument and alsomethods of treating such cancer are disclosed. Furthermore, the use of such aradiolabeled polypeptide in diagnosis and treatmentof cancer characterized by overexpression of HER2. Nucleic acids encoding thepolypeptides, expression vectors comprising thenucleic acids and host cells comprising the expression vectors are alsodisclosed.
