PROBLEM TO BE SOLVED: To provide the gene of a TCR specific to a tumor antigen or the like to make a CTL that has desired antigen specificity in a large quantity and easily.SOLUTION: A polypeptide comprises a polypeptide comprising a specific amino acid sequence or a polypeptide comprising an amino acid sequence having the deletion, addition, insertion or substitution of one to several amino acid residues in the amino acid sequence and constitutes, together with a polypeptide comprising a specific amino acid sequence an HLA-A24-restricted, MAGE-A4-specific T-cell receptor. In addition, a nucleic acid that encodes the polypeptide is disclosed.【課題】所望の抗原特異性を有するＣＴＬを大量かつ容易に調製するための、腫瘍抗原等に特異的なＴＣＲの遺伝子を提供する。【解決手段】特定のアミノ酸配列からなるポリペプチド又は該配列に１～数個のアミノ酸残基の欠失、不可、挿入もしくは置換がなされたアミノ酸配列からなるポリペプチドを有し、かつ特定のアミノ酸配列からなるポリペプチドとともにＨＬＡ－Ａ２４拘束性のＭＡＧＥ－Ａ４143-151特異的なＴ細胞レセプターを構成しうるポリペプチド、並びに該ポリペプチドをコードする核酸。【選択図】なし
