Heerociclos substituted Compounds, which induce apoptosis； Pharmaceutical Composition and its use for the treatment of various cancers, such as breast, bladder, Brain, Bone Marrow, Liver, Lymphoma, Leukemia, lymphoblastic, among others

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专利权人:

ABBVIE INC;ABBVIE IRELAND UNLIMITED COMPANY

发明人:

MANTEI ROBERT,ELMORE, STEVEN,WANG, LE,DOHERTY, GEORGE,WANG, XILU,TAO, ZHI-FU,SONG, XIAOHONG,SULLIVAN, GERARD,SOUERS, ANDREW, J.,BRUNCKO, MILAN,DING, HONG,HASVOLD, LISA,HEXAMER, LAURA,KUNZER, AARON,WAN,WANG XILU,SOUERS ANDREW J,SULLIVAN GERARD,BRUNCKO MILAN,DING HONG,DOHERTY GEORGE,HASVOLD LISA,HEXAMER LAURA,KUNZER AARON,SONG XIAOHONG,TAO ZHI-FU,WANG GARY,WANG LE,WENDT MICHAEL,HANSEN T

申请号：

CL2012003286

公开号：

CL2012003286A1

申请日:

2012.11.23

申请国别(地区):

CL

年份:

2014

代理人:

摘要：

Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.COMPUESTOS DERIVADOS DE 2-(1H-PIRROLO[2,3-B]PIRIDIN-5-ILOXI)BENZAMIDA SUSTITUIDOS, INDUCTORES DE APOPTOSIS； Y SU COMPOSICION FARMACEUTICA, UTILES COMO INHIBIDORES DE PROTEINAS BCL-2 PARA EL TRATAMIENTO DE CANCER DE VEJIGA, CEREBRO, MAMAS, MEDULA OSEA, HEPATOCELULAR, LINFOMA, LEUCEMIA LINFOBLASTICA.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/