LALIT VIJAY SONAWANE,BHAGWAT NIVRUTIRAO POUL,NEERAJ M TOUR
申请号：
IN201721025288
公开号：
IN201721025288A
申请日:
2017.07.17
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
ABSTRACT Nasal drug delivery system is a promising and challenging alternative route of administration for the several systemically acting drugs with poor bioavailability and it has advantages of quick onset of action, reduces systemic exposure and reduces the side effects, bypass the BBB and delivers the drug directly into the CNS, superior patient acceptability and compliance compared to parenteral administration of drugs. The successful application of these attributes requires careful design of characteristics of both the drug formulation and delivery device and a clear understanding of the ways in which they impact on each other. Nasal drug delivery as an antiemetic will help patient better than the use of their routes. If emesis stops, oral route becomes useful for other drugs and help of healthcare personal for administration of drugs not required. The era of nasal drug delivery is growing and new efforts are required to make this route of delivery more efficient and popular. This provides easy application of drugs, with the possibility of self administration by removing the chance of unwanted painful condition associated with injection form of drug delivery. Appropriate quantity of carbopol 934 was soaked in water for a period of 2 hours. Carbopol was then neutralized with triethanolamine (TEA) with stirring. Then specified amount of drug was dissolved in appropriate and preweighed amounts of propylene glycol and carbitol. Solvent blend was transferred to carbopol container and agitated for additional 20 min. The dispersion was then allowed to hydrate and swell for 60 min, finally adjusted pH with 98% TEA until the desired pH value was approximately reached (5-5.6). During pH adjustment, the mixture was stirred gently with a spatula until homogeneous gel was formed. The entire samples were allowed to equilibrate for at least 24 hours at room temperature prior to evaluation. Ondensetron hydrochloride was successfully formulated as mucoadhesive g
