Yong DAI,Yong WANG,Shengjin JIN,Deborah H. MESHULAM,Godfrey W. AMPHLETT,Ravi CHARI,Wei ZHANG
申请号：
US14924960
公开号：
US20160045616A1
申请日:
2015.10.28
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The invention provides processes for preparing a cell-binding agent chemically coupled to a drug. A first process comprises covalently attaching a linker to a cell-binding agent, an optional purification step, conjugating a drug to the cell-binding agent, a subsequent purification step, and optional holding steps. A second process comprises covalently attaching a linker to a cell-binding agent, a purification step, conjugating a drug to the cell-binding agent, a subsequent purification step. holding steps, and optionally a tangential flow filtration (TFF) step.
