MANOHARAN, Muthiah,RAJEEV, Kallanthottathil G.,NARAYANANNAIR, Jayaprakash K.,MAIER, Martin
申请号：
AU2020203054
公开号：
AU2020203054A1
申请日:
2020.05.08
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
#$%^&*AU2020203054A120200528.pdf#####Abstract The invention relates to a modified oligonucleotide comprising a structure shown below: Linker-LG Linker-LG Linker-LG 5 Linker-LG, Linker-LG, Linker-LG, Linker-LG Linker-LG or Linker-L LG is independently for each occurrence a ligand； and Z', Z", Z"' and Z" are each independently for each occurrence 0 or S； and wherein all of the nucleotide io sugars of the RNA agent is modified, and to a method of modulating expression of a target gene using the modified oligonucleotide. 15 56228371 (GHMatters) P84321.AU.1 PETERB 31/07/14
