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ANTIBODY-DRUG CONJUGATE
专利权人:
发明人:
Takeshi Masuda,Hiroyuki Naito,Takashi Nakada,Masao Yoshida,Shinji Ashida,Hideki Miyazaki,Yuji Kasuya,Koji Morita,Yuki Abe,Yusuke Ogitani
申请号:
US15180203
公开号:
US20160279259A1
申请日:
2016.06.13
申请国别(地区):
US
年份:
2016
代理人:
摘要:
As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-Lb-Lc- wherein the antibody is connected to the terminal of L1, and the antitumor compound is connected to the terminal of Lc with the nitrogen atom of the amino group at position 1 as a connecting position.
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