The present disclosure relates to a nucleotide sequence comprising thesequence of SEQ ID NO:5, and/or sequence of SEQ ID NO: 6, vector and host cell line comprising thenucleotide. Thepresent disclosure also relates to an antibody that binds to extracellularregion of human CD147,wherein the antibody comprises a heavy chain variable region having the aminoacid sequence ofSEQ ID NO: 2, and/or a light chain variable region having the amino acidsequence of SEQ IDNO: 1, and the antibody contains a glycoform lacking both fucose residues andxylose residues,pharmaceutical composition comprising the antibody or fragment thereof, themethod ofproducing the antibody or fragment thereof, and use of the pharmaceuticalcomposition intreatment of CD147 expression-related diseases.
