H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.;THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
发明人:
FREDERICK L. LOCKE,DARIO ALTIERI,SCOTT ANTONIA,CLAUDIO ANASETTI,DMITRY GABRILOVICH
申请号：
US16548989
公开号：
US20200017561A1
申请日:
2019.08.23
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The invention concerns a variant (double mutant form) of the survivin polypeptide； nucleic acid molecules encoding the survivin variant； antigen presenting cells (APCs) such as dendritic cells, or APC precursors, comprising the variant survivin polypeptide or encoding nucleic acid sequence； and methods for treating a malignancy, such as myeloma, or for inducing an immune response, utilizing a variant survivin polypeptide, nucleic acid molecule, or APC.
