John Lopez,Peter Draper,Sankalp Vashishtha,Nancy Klassen,Christina Armstrong
申请号:
US13574159
公开号:
US09480667B2
申请日:
2011.01.19
申请国别(地区):
US
年份:
2016
代理人:
摘要:
An NSAID formulation for encapsulation into a soft gel capsule with increased stability, concentration and bioavailability of the NSAID. The preferred NSAIDS are naproxen, ibprofen, indomethacin and diclofenac, which are provided in both an acidic and basic form in the fill formulation. The pH values of fill formulations may be adjusted without additional process steps. A process for increasing the achievable concentration of an NASAID pharmaceutical ingredient in a fill composition for dosage units is also provided. The highly concentrated NASAID formulation permits a reduction in the fill volume or dosage unit size or an increase in concentration of the NSAID in each dosage it.