Bent Karsten Jakobsen,Peter Eamon Molloy,Yi Li,Jonathan Michael Boulter
申请号：
US14249904
公开号：
US09447410B2
申请日:
2014.04.10
申请国别(地区):
US
年份:
2016
代理人:
摘要：
A proteinaceous particle, for example a bacteriophage, ribosome or cell, displaying on its surface a T-cell receptor (TCR). The displayed TCR is preferably a heterodimer having a non-native disulfide bond between constant domain residues. Such display particles may be used for the creation of diverse TCR libraries for the identification of high affinity TCRs. Several high affinities are disclosed.
