DAVID MACHNIK,JEAN-FRANCOIS SABUCO,JOSEPH MARIA GERARDUS BARBARA CALS,LAURENT SCHIO,SANDER BERNARDUS NABUURS,JOSEPH MARIA GERARDUS BAR
申请号：
BR112017026229
公开号：
BR112017026229A2
申请日:
2016.06.03
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
ror gamma modulators (rory)? the present invention relates to novel compounds according to formula i (formula i) meta or para - or a pharmaceutically acceptable salt thereof, wherein: a11 - a14 are n or cr11, cr12, cr13, cr14, respectively, provided that no more than two of the four positions a in a11-a14 can be simultaneously n； - a6, a7, a8, a9, a10 are n or cr6, cr7, cr8, cr9, cr10, respectively, provided that at least one but not more than two of the five positions a in a6, a7, a8, a9, a10 , let n； R1 is c (2-6) alkyl, c (3-6) cycloalkyl, c (3-6) cycloalkylac (1-3) alkyl, (di) and (36) cycloalkylamino or (di) (c (3 -6) cycloalkyl (1-3) alkyl) amino； - R5 is h, hydroxyethyl, methoxyethyl, c (1-6) alkyl, c (6-10) aryl, c (6-10) arylac (1-3) alkyl, c (1-9) heteroaryl, c (1 -9) heteroarylac (1-3) alkyl, c (3-6) cycloalkyl, c (36) cycloalkylac (13) alkyl, c (2-5) heterocycloalkyl or c (25) heterocycloalkylac (13) alkyl ； - the sulfonyl group with r1 is represented by one of r7, r8 or r9； R15 is h, c (1-6) alkyl, c (3-6) cycloalkyl, c (3-6) cycloalkyl (1-3) alkyl, c (6-10) aryl, c (6-10) arylac (1-3) alkyl, c (1-9) heteroaryl, c (1-9) heteroarylac (1-3) alkyl, c (2-5) heterocycloalkyl or c (2-5) heterocycloalkyl-c (1-3 ) alkyl； - and r16 is c (1-6) alkyl, c (3-6) cycloalkyl, c (3-6) cycloalkylac (1-3) alkyl, c (6-10) aryl, c (6-10) arylac ( 1-3) alkyl, c (1-9) heteroaryl, c (1-9) heteroarylac (1-3) alkyl, c (2-5) heterocycloalkyl or c (2-5) heterocycloalkyl-c (1-3) alkyl?moduladores de ror gama (rory)? a presente invenção se refere a novos compostos de acordo com a fórmula i (fórmula i) meta ou para - ou um sal farmaceuticamente aceitável deste, em que: - a11 - a14 são n ou cr11, cr12, cr13, cr14, respectivamente, contanto que não mais que duas das quatro posições a em a11-a14 possam ser simultaneamente n； - a6, a7, a8, a9,a10 são n ou cr6, cr7, cr8, cr9, cr10, respectivamente, contanto que pelo menos uma, mas não mais que duas das cinco posições a em a6, a7, a8, a9,
