KOMPOZICIJE PIROLOPIROLA KAO AKTIVATORI PIRUVAT KINAZE (PKR)

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专利权人:

FORMA THERAPEUTICS; INC.

发明人:

ERICSSON, ANNA,GREEN, NEAL,GUSTAFSON, GARY,HAN, BINGSONG,LANCIA JR., DAVID, R,MITCHELL, LORNA,RICHARD, DAVID,SHELEKHIN, TATIANA,SMITH, CHASE, C.,WANG, ZHONGGUO,ZHENG, XIAOZHANG

申请号：

RSP20200509

公开号：

RS60209B1

申请日:

2018.03.20

申请国别(地区):

RS

年份:

2020

代理人:

摘要：

The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds of formula (I) useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/