PIROLPIROLO KOMPOZICIJOS, KAIP PIRUVATO KINAZĖS (PKR) AKTYVATORIAI

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专利权人:

Forma Therapeutics; Inc.

发明人:

ERICSSON, Anna,GREEN, Neal,GUSTAFSON, Gary,HAN, Bingsong,LANCIA, JR.,MITCHELL, Lorna,RICHARD, David,SHELEKHIN, Tatiana,SMITH, Chase C.,WANG, Zhongguo,ZHENG, Xiaozhang

申请号：

LT18716455

公开号：

LT3448859T

申请日:

2018.03.20

申请国别(地区):

LT

年份:

2019

代理人:

摘要：

The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds of formula (I) useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/