Novel fusion protein comprising transcription modulation domain of P65 and protein transport domain and use thereof

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专利权人:

Sang Lee

发明人:

Lee, Sang Kyou,Park, Sung Dong,Yang, Jung-Jin

申请号：

AU2016385177

公开号：

AU2016385177A1

申请日:

2016.01.06

申请国别(地区):

AU

年份:

2018

代理人:

摘要：

The invention relates to a new fusion protein comprising a transcription modulation domain of p65 which is a subunit of the transcription factor NF-κB, and a protein transport domain and a use thereof. The fusion protein according to the present invention has the effects of inhibiting the transcription of NF-κB and IL-2 by competitive inhibition, inhibiting the secretion of inflammatory cytokines by LPS, and inhibiting the production of IL-2, IFN-γ, IL-4, IL-17A and IL-10 in splenocytes, and thus can be useful as a composition for the prevention or treatment of NF-κB hyperactivity-related diseases.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/