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APPLICANT INJECTED COMPOSITIONS
专利权人:
ИННОФАРМА; ИНК. (US)
发明人:
ХИНГОРАНИ Тушар (US),СОППИМАТ Кумареш (US),ПЕЯВЕР Сатиш (US),ПУРИ Навнеет (US)
申请号:
RU2014147365
公开号:
RU2014147365A
申请日:
2013.05.24
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A sterile liquid formulation of an aprepitant for injection, comprising: an aqueous single-phase solvent system containing water, a first co-solvent, a surfactant and a second co-solvent; where the first co-solvent and surfactant are present synergistically with respect to the solubility of the aprepitant; the second co-solvent is contained in an amount of 6 vol.% or less of the total volume of water and the first co-solvent; iaprepitant at a concentration of at least 5 mg / ml. 2. The sterile liquid composition according to claim 1, characterized in that the first co-solvent is a short-chain alcohol. The sterile liquid composition according to claim 2, characterized in that the short-chain alcohol is ethanol. 4. The sterile liquid composition according to claim 1, characterized in that the surfactant is a nonionic surfactant. The sterile liquid composition according to claim 4, characterized in that the nonionic surfactant is polysorbate. The sterile liquid composition according to claim 1, characterized in that the second co-solvent is a short-chain polyethylene glycol or dimethylacetamide. The sterile liquid composition according to claim 6, characterized in that the second co-solvent is a short-chain polyethylene glycol and is contained in an amount of 3% vol. Or less. The sterile liquid composition according to claim 6, characterized in that the second co-solvent is dimethylacetamide and is contained in an amount of 1 vol.% Or less. The sterile liquid composition according to claim 1, characterized in that the first cosolvent is ethane1. Стерильный жидкий состав апрепитанта для инъекций, содержащий:водную однофазную систему растворителей, содержащую воду, первый сорастворитель, поверхностно-активное вещество и второй сорастворитель;где первый сорастворитель и поверхностно-активное вещество присутствуют в синергическом отношении по отношению к растворимости апрепитанта;при этом второй сорастворитель содержится в количестве, составляющем 6 об.% или менее от об
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