YING, WENBIN,MINOMI, KENJIROU,HARBORTH, JENS,TAKAHASHI, HIROKAZU,TERADA, ERIKA,ZHANG, JUN,AHMADIAN, MOHAMMAD
申请号：
CA2971881
公开号：
CA2971881A1
申请日:
2015.12.28
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
This invention provides compounds, compositions and methods for modulating the expression of human GST-pi using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. Provided are a range of siRNA structures, having one or more of nucleotides being modified or chemically-modified. Advantageous structures include siRNAs with 2'-deoxy nucleotides located in the seed region, as well as other nucleotide modifications
