ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
发明人:
CREEMERS, ESTHER ELISA JOHANNA MARIA,PINTO, YIGAL-MARTIN,TIJSEN, ANKE JOHANNA MARINA
申请号：
DK10769995
公开号：
DK2425016T3
申请日:
2010.04.29
申请国别(地区):
DK
年份:
2015
代理人:
摘要：
The present invention relates to a method for diagnosing and/or prognosing heart failure in a subject the method comprising the step of determining the level of at least one genetic marker in a body fluid sample obtained from said subject, wherein said at least one genetic marker is an miRNA. The invention further relates to a method for treating or preventing heart failure in a subject the method comprising the step of decreasing within said subject the expression, amount, and/or activity of at least one miRNA, or decreasing within said subject the interaction of at least one miRNA with its mRNA target or increasing within said subject the expression, amount, and/or activity of the mRNA target of at least one miRNA.
