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Inhibition of MyBP-C binding to myosin as a treatment for heart failure
专利权人:
发明人:
Richard L. Moss,Ariel Fernandez
申请号:
US13827023
公开号:
US09051387B2
申请日:
2013.03.14
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The present invention provides for methods of treating and slowing the onset of heart failure. The inventors have determined that myosin binding to unphosphorylated Myosin Binding Protein C (MyBP-C) plays a key role in the diminution of cardiac contractile force and frequency in heart failure. The present invention provides peptide inhibitors of the MyBP-C/myosin interaction, thereby increasing both cardiac contractile force and frequency in the failing heart, as well as in patients not yet exhibiting frank heart failure.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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