The present invention discloses and claims a series of substituted N-phenyl spirolactam bipyrrolidines of formula (I).Wherein R1, R2, R3, R4, m, n, p and s are as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, this invention also discloses methods of preparation of substituted N-phenyl spirolactam bipyrrolidines of formula (I) and intermediates therefor.本發明揭示並主張一系列式(I)經取代N-苯基螺內醯胺雙吡咯啶,其中R1、R2、R3、R4、m、n、p及s如本文所定義。更具體而言,本發明之化合物是H3受體調節劑,因此可作為藥劑使用,尤其有助於治療和/或預防H3受體調控的各種疾病,包括與中樞神經系統相關的疾病。此外,本發明還揭示了式(I)經取代N-苯基螺環內醯胺雙吡咯啶及其中間體的製備方法。
