The present invention relates to a process for the preparation of 2-fluoroadenine by amidation of a 6-chloro-2-fluoropurine (CFP) compound of the following formula 1 (2-fluoropurin-6-yl) triphenylphosphine amide (FA-TPP) of the following formula (2) A second step of synthesizing a second intermediate product of 2-fluoroadenine hydrochloride (2-FA HCl) of the following formula 3 by an oxidation reaction of the first intermediate product； (2-Fluoroadenine, 2-FA) of the following formula (4) by neutralizing the intermediate product of the 2-fluoroadenine to prepare a 2-fluoroadenine do. [Chemical Formula 1] (2) (3) [Chemical Formula 4]본 발명은 2-플루오로아데닌(2-Fluoroadenine)을 제조방법에 있어서, 하기 [화학식 1]의 6-클로로-2-플루오르퓨린(6-chloro-2-fluoropurine, CFP) 화합물을 아마이드화반응시켜 하기 [화학식 2]의 (N-(2-플루오르퓨린-6-닐)트리페닐포스핀 아마이드 (N-(2-fluoropurin-6-yl)triphenylphosphine amide, FA-TPP) 제1중간생성물을 합성하는 제1단계； 상기 제1중간생성물을 산화반응시켜 하기 [화학식 3]의 2-플루오르아데닌 하이드로클로라이드(2-flouroadenine Hydrochloride, 2-FA HCl) 제2중간생성물을 합성하는 제2단계； 및 상기 제2중간생성물을 중화반응시켜 하기 [화학식 4]의 2-플루오로아데닌(2-Fluoroadenine, 2-FA)을 합성하는 제3단계로 구성되는 2-플루오로아데닌(2-Fluoroadenine) 제조방법을 제공한다.[화학식 1] [화학식 2][화학식 3][화학식 4]
