BENZYLIDENE INDANONES USEFUL AS ANTICANCER AND TUBULIN POLYMERISATION INHIBITORS AND PROCESS FOR PREPARATION THEREOF
- 专利权人:
- 发明人:
- 申请号：
- IN2769/DEL/2011
- 公开号：
- IN291668B
- 申请日:
- 2011.09.22
- 申请国别(地区):
- IN
- 年份:
- 2018
- 代理人:
- 摘要：
The present invention relates to benzylidene indanones of general formula 1. The compounds exhibited tubulin polymerisation inhibition. A series of compounds 2-benzylidene 3-(3,4,5-trimethoxyphenyl) indanones having general formulae 1 were synthesized from gallic acid through a chemical process. 2-(3,4-Methylenedioxybenzylidine), 3-(3,4,5-trimethoxyphenyl), 4,5,6-trimethoxyindanone (8), a representative compound of this series possessing the molecular formulae C29H28O9, was synthesized from gallic acid and exhibits potent anticancer activity. Compound 8 was evaluated for acute oral activity in Swiss albino mice and found to be safe up to 300 mg/kg body weight. The anticancer activity of the compounds has been determined, in order to obtain new potent and cost effective molecules using an in vitro cytotoxicity assay.
[US2013079396A1]
- 来源网站：
- 中国工程科技知识中心
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