XIAOHONG SONG,TODD M. HANSEN,GERARD M. SULLIVAN,ROBIN FREY,ANDREW JUDD,ANDREW SOUERS,LE WANG,GEORGE DOHERTY,XILU WANG,ZHI TAO,MILAN FU - BRUNKO,AARON R. KUNZER,MICHAEL D. WENDT
申请号：
ARP120103811
公开号：
AR088327A1
申请日:
2012.10.12
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
Compounds that inhibit the activity of the antiapoptotic Protein BCL XL, compositions containing such compounds and Methods for treating diseases in which expressing the antiapoptotic Protein BCL XL.Claim 1: wherein is a compound of the formula (1) or a Salt thereof acceptable to Therapy, where X is represented by the heteroaryl heteroaryl； where X is optionally substituted with one, two, three, or four r u2074； y u00b9 is heteroarileno phenylene or c u2085 u208b u2086； option Normally one or two FUSED rings, selected from the group consisting cicloalcano c u2083 u208b u2088,Cicloalqueno c u2083 u208b u2088, benzene, heteroareno c u2085 u208b u2086, heterocicloalcano c u2083 u208b u2088, and heterocicloalqueno c u2083 u208b u2088； where y u00b9 is optionally substituted with one, two, three, or four substituents selected independently from the group consisting r u2075, or u2075, sr u2075 (R, S) u2075, so u2082r u2075, r u2075 co C (OR), (OR) r u2075, OC (OC r u2075 or), (OR) or u2075, nh u2082, nhr u2075, N (r u2075) u2082, NHC (OR) r u2075, nr u2075c (or NHS) r u2075, u2082r u2075 nr u2075s (OR), (OR) u2082r u2075, NHC (or u2075 or), (OR) or u2075, nr u2075cNHC (OR) nh u2082, NHC (OR) nhr u2075, NHC (o) n (r u2075 u2082 nr u2075c), (OR) nhr u2075, nr u2075c (o) n ( u2082 r u2075), C (o) C (o) nh u2082, nhr u2075, C (o) n ( u2082 r u2075), C (o) nhoh, nhor u2075, C (o) C (o) C (o) nhso u2082r u2075, nr u2075so u2082r u2075, so u2082nh u2082, so u2082nhr u2075, so u2082n (r u2075) u2082, CO (o) C (o) h, h, Oh, CN, n u2085, no u2082, F, CL, BR and I l u00b9 choose between； The Group consists of (Q, cr u2076r u2077) ( u209b cr u2076r u2077) - or - (cr u2076r u2077) u02b3, u209b (cr u2076r u2077) - C (o) - (cr u2076r u2077) u02b3, u209b (cr u2076r u2077) - S - (cr u2076r u2077) u02b3, u209b (cr u2076r u2077) - S (o) u2082 - (cr u2076r u2077) u02b3 (cr u2076r u2077 u209b nr u2076ac) - (OR) - ( u02b3, cr u2076r u2077)( u209b cr u2076r u2077) - C (o) - ( u02
