Bernhard K. Mueller,Martin Schmidt,Eve Barlow,Mary Leddy,Chung-Ming Hsieh,Philip Bardwell
申请号：
US15832177
公开号：
US20180162933A1
申请日:
2017.12.05
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind and neutralize RGM A protein. Specifically, these antibodies have the ability to inhibit the binding of RGM A to its receptor and/or coreceptors. These antibodies or portions thereof of the invention are useful for detecting RGM A and for inhibiting RGM A activity, for example in a human suffering from a disorder including but nor limited to multiple sclerosis, mammalian brain trauma, spinal cord injury, stroke, neurodegenerative diseases, and schizophrenia.
