Nanjing Medical University Affiliated Brain Hospital
发明人:
SHEN, Hong,XIAO, Hong,LI, Rui
申请号：
AU2020100423
公开号：
AU2020100423A4
申请日:
2020.03.19
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
#$%^&*AU2020100423A420200910.pdf#####Abstract The present invention relates to the field of medicine, and specifically relates to an angiogenesis agonist polypeptide, a polypeptide that can treat ischemic disease. In particular, a sequence of the polypeptide is a new sequence, having an effect of promoting angiogenesis. It is used for treatment of ischemic stroke. The beneficial effect of the present invention is that the sequence of the present invention is a novel small-molecule polypeptide truncated from GPR124 cell membrane surface receptor sequence protein and modified to specifically link integrin receptor with angiogenesis activity. The sequence of the polypeptide can specifically bind to integrin and has the ability to regulate cells in adhesion and migration during angiogenesis, thereby playing a role in the treatment of ischemic diseases.
