6S and (9aS) -N-Benji Lu 6- [(4-hydroxyphenyl) Methyl] -4, 7-dioxo 8 - ({6- [3- ( Piperazine - 1- Il ) azetidine 1- Il ] pyridine 2- Il } methyl) -2 - (prop 2- En - 1- Il ) - Crystal of an octahydro 1H-pyrazino [2 and 1-] [c] [1, 2, 4] triazine 1- Carboxamide compound

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专利权人:

LTD.;EISAI R&D MANAGEMENT CO.

发明人:

IKUO KUSHIDA,YOKO ITO

申请号：

BR112017025519

公开号：

BR112017025519A2

申请日:

2016.06.21

申请国别(地区):

BR

年份:

2018

代理人:

摘要：

the present invention provides a (6s, 9as) -n-benzyl-8 - ({6- [3- (4-ethylpiperazin-1-yl) azetidin-1-yl] pyridin-2-yl} methyl) - 6- (2-fluoro-4-hydroxybenzyl) -4,7-dioxo-2- (prop-2-en-1-yl) hexahydro-2h-pyrazine [2,1-c] [1,2,4] triazine-1 (6h) -carboxamide.a presente invenção proporciona um cristal de (6s,9as)-n-benzil-8-({6-[3-(4-etilpiperazin-1-il)azetidin-1-il]piridin-2-il} metil)-6-(2-fluoro-4-hidroxibenzil)-4,7-dioxo-2-(prop-2-en-1-il) hexaidro-2h-pirazino [2,1-c][1,2,4] triazina-1(6h)-carboxamida.

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