Being something regarding the kit in order to use for hormone characteristic contraceptive method or the hormone supplement medical therapy in the mammalian woman, the aforementioned kit at least 1g which is chosen from the group which consists of the estrogen and the professional guest gene 1 or the plural steroids At least 0.1mg which is chosen from the group which consists of the gurutamiru derivative of the salt and these tetrahydrofolic folic acid which are allowed (6S) - tetrahydrofolic folic acid, 5 - methyl - (6S) - tetrahydrofolic folic acid, 5 - the formyl - (6S) - tetrahydrofolic folic acid, 10 - the formyl - (6R) - tetrahydrofolic folic acid, 5,10 - methylene - (6R) - tetrahydrofolic folic acid, 5,10 - methenyl - (6R) - tetrahydrofolic folic acid, 5 - horumuimino - (6S) - as the medicine of tetrahydrofolic folic acid and these tetrahydrofolic folic acid 1 or the plural tetrahydrofolic folic acid chemical compound components And 10 where at least the vitamin B12 of 0.1mg is included oral medication units are included at least. As for other viewpoint of this invention, 1 where the medication unit in the mammalian woman is included or being the hormone characteristic contraceptive method which includes at least the oral administration of 1 day 1 time of the plural steroids and something regarding hormone substitution medical therapy, that time the said medication unit at least 0.1 mg 1 or the plural above-mentioned tetrahydrofolic folic acid chemical compound components and includes the vitamin B12 of 0.1 mg at least additional.哺乳類の女性におけるホルモン性避妊薬法またはホルモン補充療法に使用するためのキットに関するものであって、前記キットは エストロゲンおよびプロゲストゲンからなる群から選ばれる少なくとも1μg の1又は複数のステロイド;(6S)-テトラヒドロ葉酸、5-メチル-(6S)-テトラヒドロ葉酸、5-ホルミル- (6S)-テトラヒドロ葉酸、10-ホルミル-(6R)-テトラヒドロ葉酸、5,10-メチレン- (6R)-テトラヒドロ葉酸、5,10-メテニル-(6R)-テトラヒドロ葉酸、5-ホルムイミノ-(6S)-テトラヒドロ葉酸、これらのテトラヒドロ葉酸の医薬として許容される塩およびこれらのテトラヒドロ葉酸のグルタミル誘導体からなる群から選ばれる少なくとも0.1mg の1又は複数のテトラヒドロ葉酸化合物成分;ならびに少なくとも0.1mgのビタミンB12を含む少なくとも10経口投薬単位を含む。本発明の他の観点は、哺乳類の女性における投薬単位を含む1又は複数のステロイドの少なくとも1日
