ALKYL 2-{[(2R,3S,5R)-5-(4-AMINO-2-OXO-2 -PYRIMIDIN-1-YL)-3-HYDROXY- TETRAHYDRO-FURAN-2-YL-METHOXY]-PHENOXY-PHOSPHORYL-AMINO}-PROPIONATES, NUCLEOSIDE INHIBITORS OF HCV NS5B RNA-POLYMERASE, AND METHODS FOR PRODUCING AND USE THEREOF

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专利权人:

发明人:

申请号：

EP14770263.3

公开号：

EP2977379A1

申请日:

2014.02.19

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

Compounds of the general formula 1, stereoisomers, pharmaceutically acceptable salts, and/or hydrates, solvates or crystalline forms thereofwhereinR1 represents C1-C4 alkylR2 and R3 represents fluoro, orR2 represents fluoro, and R3 represents methylR4 and R5 represents hydrogen, orR4 represents C1-C6 acyl, and R5 represents hydrogen, orR4 represents hydrogen, and R5 represents C1-C6 acyl, orR4 represents optionally substituted α-aminoacyl, and R5 represents hydrogen, orR4 represents hydrogen, and R5 represents optionally substituted α-aminoacylR6 represents hydrogen, methyl, methoxy or halogen.

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