Use of compounds of the following formula (I): ** Formula ** in which: - R1, R2 and R3, identical or different and independently of each other, represent a hydrogen or halogen atom, a hydroxyl radical , an alkyl, perfluoroalkyl, alkoxy, alkylthio, nitrile, a substituted alkoxy, or a fused heterocycle group obtained from two of the adjacent radicals R1, R2 and R3, which may form, together with the carbon atoms of the phenyl cycle to which they are attached, a fused heterocycle, - X represents a sulfur or oxygen atom, - Y represents a mono- or polycyclic, substituted or unsubstituted heteroaryl group, a group -NH- (C>； = O) -R6, - (C>； = O) -NH-R6 or -NH- (C>； = O) -NH-R6, in which R6 represents an unsubstituted aryl group； an aryl group comprising one or more substituents chosen from a halogen atom and an alkyl, alkoxy or mono- or dialkylamino radical； a mono- or polycyclic heteroaryl group； a linear or branched alkyl radical； a saturated or unsaturated mono- or polycyclic hydrocarbon group； - R4 and R5, identical or different and independently of each other, represent a hydrogen or halogen atom, an alkoxy, alkylthio, alkyl, perfluoroalkyl, nitrile or nitro group, for the manufacture of a medicament for the treatment of associated tumors at a hyperactivation of the signaling pathway of Hedgehog proteins, said tumors being chosen among nerve tissue tumors (medulloblastomas, primary neuroectodermal tumors, glioblastomas, meningiomas and oligodendrogliomas), skin tumors (basal cell carcinomas, tricoepitheliomas), tissue tumors muscle and bone (rhabdomyosarcomas, osteosarcomas) or tumors of other tissues (kidney, gallbladder) or pathologies of neurodegenerative type chosen between sclerosis in plaques or motor neuron disease.Utilización de compuestos de la fórmula (I) siguiente:**Fórmula** en la que: - R1, R2 y R3, idénticos o diferentes e independientemente los unos de los otros, representan un átomo de hidrógeno o de halógeno, un radical hidroxilo, un grupo alqui
