A biopsy assembly including a biopsy catheter having a proximal portion and a distal portion, a navigation catheter configured to receive the biopsy catheter for positioning the biopsy catheter adjacent target tissue, wherein the biopsy catheter is configured to be received within the navigation catheter, a coring component, and an anchoring component configured to anchor the biopsy catheter to target tissue. The coring component includes a proximal region and a distal region, the distal region formed of one or more distally extending blades and the proximal region being coupled to the distal portion of the biopsy catheter and the one or more blades are configured to penetrate target tissue and sever a tissue sample from the target tissue.
