Лобко Владимир Павлович (RU),Челяева Анастасия Геннадьевна (RU)
申请号：
RU2015118905
公开号：
RU2015118905A
申请日:
2013.04.18
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. An antitumor agent comprising bortezomib, mineral substances in the following ratio, mg / kg: wherein the antitumor agent is in the form of a solid dosage form using a pharmaceutically acceptable additive material and an antineoplastic agent is configured such that it comprises isotopes uglerodaS and uglerodaS isotope ratio of the total amount of carbon in the solid dosage form is a size from 0.003 to 0,75.2. An antitumor agent comprising bortezomib, mineral substances in the following ratio, mg / kg: wherein the antitumor agent is in the form of a solid dosage form using a pharmaceutically acceptable additive material and an antineoplastic agent is configured such that it comprises isotopes uglerodaS and amount ratio isotopes uglerodaS to the total amount of carbon in the solid dosage form is a size from 0.003 to 0.75, and the antitumor agent comprises isotopes azotaN and isotopes azotaN ratio of the total amount of nitrogen in the solid dosage form is a size from 0.0001 to 0.1375.3. An antitumor agent comprising bortezomib, executed in a solid dosage form using a pharmaceutically acceptable additive material wherein bortezomib content in the solid dosage form from 1 × 10to 850 · 10 mg / kg and anti-tumor agent is configured such that it comprises isotopes uglerodaS and uglerodaS isotope ratio of the total amount of carbon in the solid dosage form is a size from 0.003 to 0.75, and1. Противоопухолевое средство, содержащее бортезомиб, минеральные вещества, при следующем соотношении компонентов, мг/кг:Бортезомиб 1·103-850·103 Натрий 0,02-2400,0 Калий 0,01-1050,0,при этом противоопухолевое средство выполнено в виде твердой лекарственной формы с использованием фармацевтически приемлемого дополнительного веществаи противоопухолевое средство выполнено таким образом, что содержит изотопы углерода 13С, и отношение количества
