Systems and methods for medication management are provided. Some embodiments provide for a portable medication management and monitoring system for eye drop instillation in ocular chronic conditions. At least one embodiment includes a device having one or more of the following elements: (a) a jacket that goes around an eye drop bottle； (b) tactile sensors to detect the user's fingers and generate data to activate the system； (c) motion sensors to detect the motion of the medication bottle when it is grabbed and moved by the user； (d) a wireless communication module to send and receive data to a computer and portable communication devices； and/or (e) a compartment for holding the electronic components.
