Inhalation devices, systems, and methods for the administration of powdered medicaments to mechanically ventilated subjects are provided. In one embodiment, an inhalation device adaptively connected at one end to an air source and at the other end is operatively disposed to a ventilator circuit is provided. The inhalation devices are capable of causing a powdered medicament within a container held by the device to be dispensed from the container into the lungs of a mechanically ventilated subject.
