国立大学法人北海道大学;NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
发明人:
SEINO Ken-ichiro,清野研一郎,WADA Haruka,和田 はるか
申请号：
JPJP2019/047991
公开号：
WO2020/121988A1
申请日:
2019.12.09
申请国别(地区):
JP
年份:
2020
代理人:
摘要：
The present invention pertains to a cell formulation for inducing immune tolerance in a recipient subject that includes immune cells derived from a donor subject. The present invention also pertains to a method for evaluating the immunosuppressive action or immune tolerance action of a test treatment, the method including: a step for transplanting, into a recipient mouse the H-2 antigen type of which is b/k, cells or tissue derived from a donor mouse the H-2 antigen type of which is b/b, k/k, or b/k and the minor histocompatibility antigen type of which does not match that of the recipient mouse； a step for subjecting the recipient mouse to the test treatment； a step for evaluating the rejection reaction of the recipient mouse； and a step for comparing the rejection reaction of the recipient mouse with the rejection reaction of a control recipient mouse into which cells or tissue derived from the donor mouse was transplanted but which was not subjected to the test treatment, and assessing that the test treatment has an immunosuppressive action or immune tolerance action when the rejection reaction of the recipient mouse subjected to the test treatment is weaker than the rejection reaction of the control recipient mouse.La présente invention concerne une formulation cellulaire pour induire une tolérance immunitaire chez un sujet receveur qui comprend des cellules immunitaires dérivées d'un sujet donneur. La présente invention concerne également un procédé d'évaluation de l'action immunosuppressive ou de l'action de tolérance immunitaire d'un traitement d'essai, le procédé comprenant : une étape consistant à transplanter, dans une souris receveuse dont le type d'antigène H-2 est b/k, des cellules ou des tissus dérivé(e)s d'une souris donneuse dont le type d'antigène H-2 est b/b, k/k, ou b/k et dont le type d'antigène mineur d'histocompatibilité ne correspond pas à celui de la souris receveuse ； une étape consistant à soumettre la souris receveuse au traitement d'essai
